PEP-SELANK • RESEARCH USE ONLY

Selank

Selank is an anxiolytic and nootropic peptide that reduces anxiety while supporting focus, emotional stability, and cognitive performance—without sedative effects. It modulates GABAergic and serotonergic pathways, promoting calm mental clarity and stress resilience.

10 mg

Per Bottle
62 mcg per spray

>99%

Purity
Third-party verified

160

Sprays per bottle
Protocol & Dosing

    Use 2–3 times per day, depending on stress levels, cognitive demand, or mood needs.

    Overview: 200–1000 mcg per day, taken in 2–3 split doses (morning, midday, pre-workout for stronger effects).

Low dose Calm focus/light anxiety
186 mcg (3 sprays)
Medium dose Daily anxiety, mood, focus
250 mcg (4 sprays)
Higher dose Strong anxiety, high stress, cognitive demand
375 mcg (6 sprays)
Cycles
  • May be used daily for 8–12 weeks
  • Take 1 week off every 8–12 weeks to maintain sensitivity
Key Benefits

Reduces anxiety and stress, enhances focus and mental clarity, supports mood balance, may improve memory and learning, and promotes calm productivity without jitteriness or sedation.

Guidance
  • For daytime productivity and focus → morning dosing is ideal
  • For anxiety or emotional regulation → morning and late afternoon dosing works well
  • Selank does not require fasted dosing:
  • May be taken with or without food
  • Food does not affect calming or cognitive benefits
  • Selank is suitable for long-term use when properly cycled.
  • Start with 3 sprays per day, split into 1–2 doses
  • Increase gradually only if needed
  • May split dosing morning / midday / late afternoon
  • Do not exceed 6 sprays per day unless directed
  • Ideal for anxiety reduction, emotional balance, focus, and stress resilience
  • Non-sedating and well tolerated
  • Pairs well with Semax, NAD+, or DSIP depending on cognitive or sleep goals
PROPRIETARY DELIVERY TECHNOLOGY

Protixa ION System™

Nasal delivery is facilitated with the Protixa ION System — a proprietary liquid ion delivery platform engineered for enhanced bioavailability, deep tissue penetration, and improved compound stability without compromising safety. Unlike carriers that rely on encapsulation, it enables direct solubilization and optimized partitioning of actives including peptides and coenzymes — no liposomes, no lipid nanoparticles, no emulsifier-dependent payloads. Built from amino acids and endogenous molecules for biocompatibility; scalable across routes that include intranasal sprays.

Lipid disruption & cation exchange
Alkyl chains intercalate into the stratum corneum lipid matrix via hydrophobic interactions, reducing cohesion and increasing permeability. Cationic components displace native ions such as Ca²⁺ within lipid lamellae, weakening structural integrity so actives pass through more efficiently.
Dual-polarity solubilization
Hydrophilic and lipophilic character solubilizes and transports a broad range of actives directly — without emulsifiers or encapsulating carriers.
Keratin modulation & partitioning
Temporarily denatures keratin within corneocytes, opening transient micro-pathways for epithelial migration. Improves solubility and skin partitioning while maintaining proprietary differentiation for IP — inspired by systems like CAGE (choline–geranic acid ionic liquids).
Superior loading vs. lipid carriers
Solubilizes actives directly instead of inefficient encapsulation. In-house studies: lipid-based carriers penetrated only ~22 μm — insufficient for meaningful absorption — whereas the Protixa ION System reaches therapeutically relevant layers.
>57× vs. saline · <10 nm (DLS)
>57× barrier penetration vs. saline in an ex vivo epithelial model (Protixa third-party data). Minimum confirmed nanoparticle size under 10 nm — mucus-penetrating ionic clusters by dynamic light scattering.
Safety, stability & distribution
ISO 10993-5 CCK-8 assay: 80–100% viability at 24 h and 48 h. Four-month room-temperature stability: 101.1–101.9% HPLC recovery — no cold chain. In vivo oral mouse study: systemic distribution across five organs at 1 hour post-dose.

Compliance · Nasal peptides

cGMP manufacturing & cryopreservation

Manufactured through Pacific Manufacturing & Design LLC — GMP-certified under NSF/ANSI 455-2 and FDA-registered (Reg. No. 15492349536). Compliant with 21 CFR Parts 11, 111, and 117. Strict quality control, validated processes, and full traceability from raw material to final product.

NSF/ANSI 455-2FDA REGISTERED21 CFR PART 11121 CFR PART 117
Third-Party COA — Every Batch

Third-party COA for every batch, ensuring consistent quality and purity. Verified through LCMS and endotoxin testing, with full traceability from raw material to final product.

LCMS CONFIRMED>99% PURITYENDOTOXIN TESTEDAXISPHARM COA