PEP-SEMAX • RESEARCH USE ONLY

Semax

Semax is a nootropic and neuroprotective peptide derived from an ACTH fragment. It enhances cognitive function, memory, learning, motivation, and mental stamina while supporting neuroplasticity through increased BDNF signaling.

10 mg

Per Bottle

— 62 mcg per spray

>99%

Purity

— Third-party verified

160

Sprays per bottle

Protocol & Dosing

Use 2–3 times per day, depending on cognitive demand and stress levels.

Overview: 200–1000 mcg per day, taken in 2–3 split doses (morning, midday, pre-workout for stronger effects).

Low dose Mild cognitive boost

186 mcg (3 sprays)

Medium dose Daily productivity/mood

250 mcg (4 sprays)

Higher dose Intense work, study, or pre-workout focus

375 mcg (6 sprays)

Cycles

Use for 8–12 weeks
Take 1 week off after each cycle to maintain sensitivity and responsiveness

Key Benefits

Enhances focus and concentration, improves memory and learning, supports neuroprotection, boosts productivity and motivation, stabilizes mood, and enhances long-term brain health.

Guidance

Morning: productivity, mood, and motivation
Midday: sustained focus and mental stamina
Pre-workout or high-demand periods: optional third dose
Avoid late evening use if Semax increases alertness or interferes with sleep. Semax does not require fasted dosing:
May be taken with or without food
Food does not interfere with cognitive or neurotrophic effects
Start with 3 sprays per day, split into 1–2 doses
Increase gradually only if needed
May split dosing morning / midday / pre-workout
Do not exceed 6 sprays per day unless directed
Ideal for focus, productivity, memory, learning, and neuroprotection
Non-stimulant and well tolerated
Pairs well with Selank, NAD+, or SS-31 depending on cognitive and energy goals

PROPRIETARY DELIVERY TECHNOLOGY

Protixa ION System™

Nasal delivery is facilitated with the Protixa ION System — a proprietary liquid ion delivery platform engineered for enhanced bioavailability, deep tissue penetration, and improved compound stability without compromising safety. Unlike carriers that rely on encapsulation, it enables direct solubilization and optimized partitioning of actives including peptides and coenzymes — no liposomes, no lipid nanoparticles, no emulsifier-dependent payloads. Built from amino acids and endogenous molecules for biocompatibility; scalable across routes that include intranasal sprays.

Lipid disruption & cation exchange

Alkyl chains intercalate into the stratum corneum lipid matrix via hydrophobic interactions, reducing cohesion and increasing permeability. Cationic components displace native ions such as Ca²⁺ within lipid lamellae, weakening structural integrity so actives pass through more efficiently.

Dual-polarity solubilization

Hydrophilic and lipophilic character solubilizes and transports a broad range of actives directly — without emulsifiers or encapsulating carriers.

Keratin modulation & partitioning

Temporarily denatures keratin within corneocytes, opening transient micro-pathways for epithelial migration. Improves solubility and skin partitioning while maintaining proprietary differentiation for IP — inspired by systems like CAGE (choline–geranic acid ionic liquids).

Superior loading vs. lipid carriers

Solubilizes actives directly instead of inefficient encapsulation. In-house studies: lipid-based carriers penetrated only ~22 μm — insufficient for meaningful absorption — whereas the Protixa ION System reaches therapeutically relevant layers.

>57× vs. saline · <10 nm (DLS)

>57× barrier penetration vs. saline in an ex vivo epithelial model (Protixa third-party data). Minimum confirmed nanoparticle size under 10 nm — mucus-penetrating ionic clusters by dynamic light scattering.

Safety, stability & distribution

ISO 10993-5 CCK-8 assay: 80–100% viability at 24 h and 48 h. Four-month room-temperature stability: 101.1–101.9% HPLC recovery — no cold chain. In vivo oral mouse study: systemic distribution across five organs at 1 hour post-dose.

Compliance · Nasal peptides

cGMP manufacturing & cryopreservation

Manufactured through Pacific Manufacturing & Design LLC — GMP-certified under NSF/ANSI 455-2 and FDA-registered (Reg. No. 15492349536). Compliant with 21 CFR Parts 11, 111, and 117. Strict quality control, validated processes, and full traceability from raw material to final product.

NSF/ANSI 455-2FDA REGISTERED21 CFR PART 11121 CFR PART 117

Third-Party COA — Every Batch

Third-party COA for every batch, ensuring consistent quality and purity. Verified through LCMS and endotoxin testing, with full traceability from raw material to final product.

LCMS CONFIRMED>99% PURITYENDOTOXIN TESTEDAXISPHARM COA