MUSE • RESEARCH USE ONLY

Muse Cells

Name: Muse Cells
SKU: MUSE

SSEA-3-positive multilineage-differentiating stress-enduring (Muse) cells enriched from Wharton's Jelly in umbilical cord tissue. A rare, non-tumorigenic, pluripotent-like subpopulation of the mesenchymal compartment, studied for selective homing to damaged tissue, engraftment, and differentiation across all three germ layers. Manufactured under cGMP conditions and cryopreserved.

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SSEA-3+ · CD105+

IDENTITY

— Selected on the embryonic-type surface marker SSEA-3 alongside mesenchymal markers; expresses Nanog, Oct3/4, and Sox2 without genetic manipulation.

Non-tumorigenic

SAFETY PROFILE

— Low telomerase activity and a normal karyotype; no teratoma formation reported in immunodeficient mouse models, unlike ES and iPS cells.

Homing · engraftment

TISSUE BEHAVIOR

— Senses S1P released by damaged tissue via S1PR2 and, in preclinical models, differentiates into cells matching the local microenvironment.

ROUTES, FORMATS & APPLICATIONS

Routes

Quantities

5 Million Cells		1ml
10 Million Cells		2ml
25 Million Cells		5ml

Potential Applications

These are experimental use cases, provided as a scientific reference for researchers. Except where noted, they did not use Akira Biotech materials, and results may not be reproducible with ours. Akira Biotech supplies laboratory reagents for research use only. Our products are NOT approved by FDA or any regulatory authority and are not for use in or on humans.

Ischemic cardiovascular injury
Stroke and ischemic neural injury
Spinal cord injury and neurodegeneration
Neonatal hypoxic-ischemic injury
Chronic skin ulcer
Epidermolysis bullosa
Liver, kidney, and lung injury

PRODUCT PROFILE

Why Muse Cells Are Distinct

Muse cells are a rare SSEA-3-positive subpopulation of the mesenchymal compartment, first described in 2010. They combine pluripotent-like marker expression and triploblastic differentiation with non-tumorigenic behavior, making them a distinct tool from both bulk MSCs and ES/iPS cells.

SSEA-3 selection

Enriched on the SSEA-3 surface marker, which separates Muse cells from the remaining mesenchymal population.

Non-tumorigenic

Low telomerase activity and a normal karyotype; no teratoma formation reported in immunodeficient mice.

Stress endurance

Originally isolated by their resistance to severe cellular stress, a property thought to aid survival in damaged tissue.

Low immunogenicity

HLA-G expression and immunomodulatory factors support allogeneic use without HLA matching in published clinical studies.

Compliance · Stem cells